Immune-Mediated Effects of the Integrin avb8 Inhibitors to Enhance Antitumor Efficacy

Time: 2:30 pm
day: Day One


  • Activation of TGF-β by αvβ8-expressing cells enhances tumor tolerance
  • αvβ8 inhibition is sufficient to reverse TGF-β-driven immunosuppression
  • αvβ8 inhibition on tumor and/or immune cells impairs regulatory mechanisms while unleashing a potent antitumor immunity