Reprograming the immunosuppressive tumour microenvironment with selective integrin inhibition

Time: 2:00 pm
day: Day One


  • Inhibition of avb8 and avb1 promotes ifng and suppresses tgfb signalling in tumors
  • Reprograming tumor cytokine levels promotes proinflammatory cell infiltration and suppress stromal protein synthesis
  • Treatment was synergistic with checkpoint inhibitors in multiple murine tumor models