Pre-Conference Focus Day

Tuesday August 30, 2022

Integrins 101

9:00 am Inside Out, Outside In: A Guide to Integrin Signaling

Synopsis

  • Overcome the complexity of integrin signaling to understand the inside out and outside in signaling and explore the downstream cascades of blocking different aspects of this signaling
  • Intracellular signaling, 3D models

11:00 am Roundtable Discussion:

Synopsis

Join your peers to discuss:

  • Updates on the structural biology of integrins and subunits
  • In depth discussions on Integrin Signalling
  • Ask questions, share with and learn from your peers on all things integrin

12:00 pm
Networking Lunch

1:00 pm Integrins: How Not to Discover a Drug

  • Dermot Cox Associate Professor Pharmacy & Biomolecular Sciences, Royal College of Surgeons, Ireland

Synopsis

  • Covering the agonist-like activity of anti-integrins, pharmacokinetics and dosing levels to discover the reasons behind the level of inhibition and why
  • Taking a look at the types of inhibitor specific for a single receptor and more broad specificity, looking at should inhibitors target resting or activated receptors

3:00 pm Exploring the Mechanism of Activation & Inhibition of Integrin Function

Synopsis

  • Looking at why integrins have often failed as drug candidates and how to overcome these problems as drugs, for drug targeting, for molecular imaging and for biomaterials

5:00 pm Roundtable Discussion:

Synopsis

Finish up your Integrin 101 day with an open discussion with our expert speakers to ensure all your questions are
answered, including:

  • The binding of integrins
  • The role of integrins in autoimmune diseases, opthalmic disorders and more

6:00 pm
End of Pre-Conference Day